To bridge the gap between basic research and applied research and to drive the implementation and application of ‘fit-for-purpose’ mechanism-based in vitro tools assays, in silico tools and NAMs 3RSMC has established an extensive network spanning the 7 industrial sectors. The 3RSMC mission comprises (i) connecting test developers with test users to build confidence and drive acceptance by individual companies through small ab initio studies, (ii) validation of these ‘fit-for-purpose’ methods addressing regulatory needs, and (iii) building confidence in test approaches/strategies through application.